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Description

Methadone belongs to a class of drugs known as opioid (narcotic) analgesics. It works in the brain to change how your body feels and responds to pain.

Indications and Usage

This medication is used to treat severe ongoing pain (such as due to cancer). Methadone belongs to a class of drugs known as opioid (narcotic) analgesics. It works in the brain to change how your body feels and responds to pain.
This medication is also used to treat addiction to opioids (such as heroin) as part of an approved treatment program. It helps prevent withdrawal symptoms caused by stopping other opioids.

Contraindications

Do not use this medication to relieve pain that is mild or that will go away in a few days (such as pain from surgery). This medication is not for occasional (“as needed”) use.

Side Effects

Nausea, vomiting, constipation, lightheadedness, dizziness, dry mouth, drowsiness, or sweating may occur. Some of these side effects may decrease after you have been using this medication for a while. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

As with other opioid medications, tolerance and dependence usually develop with repeated doses. There is some clinical evidence that tolerance to analgesia is less with methadone compared to other opioids; this may be due to its activity at the NMDA receptor. Tolerance to the different physiological effects of methadone varies; tolerance to analgesic properties may or may not develop quickly, but tolerance to euphoria usually develops rapidly, whereas tolerance to constipation, sedation, and respiratory depression develops slowly (if ever).

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